Several class-A G protein-coupled receptor (GPCR) proteins act as constitutive phospholipid scramblases. Here we combined extensive molecular dynamics simulations with tICA and Markov State Models to unravel how a G Protein-Coupled Receptor flips lipids.
- Journal article: Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin, Giulia Morra, Asghar M. Razavi, Kalpana Pandey, Harel Weinstein, Anant K. Menon, George Khelashvili, Structure 26: 356–367, 2018
- Poster: Morra G., Razavi A., Pandey K., Weinstein H., & Menon A., Khelashvili G. (2018, February).The GPCR Opsin Translocates Lipids via a Dynamic Mechanism Specified by Markov State Model Analysis of Molecular Dynamics Trajectories. Poster presentation conducted at the meeting of the Biophysical Society, San Francisco, CA.