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Dopamine Transporter

The dopamine transporter (DAT) is a membrane protein belonging to the Neurotransmitter:Sodium Symporter (NSS) family, which also includes the closely related serotonin and norepinephrine transporters. NSS are responsible for clearance of released neurotransmitters (e.g. dopamine, by DAT) from the synaptic cleft. Function of NSS transporters in neuronal signaling implicate them in the mechanisms of action of abused psychostimulants, such as cocaine and amphetamine, and in various psychiatric and neurological disorders including drug addiction, schizophrenia, and Parkinson’s disease.

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About the author asgharrazavi

Asghar Razavi is a postdoctoral associate at the Department of Physiology and Biophysics at Weill Cornell Medical College of Cornell University. He received his Ph.D. in Computational Chemistry and Biophysics from Temple University, Philadelphia, USA. His current research at the Weinstein lab focuses on developing molecular level quantitative kinetic models to understand thermodynamics, kinetics, and conformational pathways during function of neurotransmitter transporters and G protein-coupled receptors.

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